GERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Aspergillus fumigatus F37. I. Production, isolation, and physico-chemical and biological properties.
نویسندگان
چکیده
GERI-BP001 compounds, new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 microM, respectively.
منابع مشابه
GLISOPRENINS, NEW INHIBITORS OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Gliocladium sp. FO-1513 I. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES HlROSHI TOMODA, XlN-Hui HUANG, HlROYUKI NlSHIDAf, ROKURO MASUMA,
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 48 8 شماره
صفحات -
تاریخ انتشار 1995